Impact of Wines and Wine Constituents on Cyclooxygenase-1, Cyclooxygenase-2, and 5-Lipoxygenase Catalytic Activity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F14%3A00429537" target="_blank" >RIV/61389030:_____/14:00429537 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1155/2014/178931" target="_blank" >http://dx.doi.org/10.1155/2014/178931</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2014/178931" target="_blank" >10.1155/2014/178931</a>

Result language

angličtina

Original language name

Impact of Wines and Wine Constituents on Cyclooxygenase-1, Cyclooxygenase-2, and 5-Lipoxygenase Catalytic Activity

Original language description

Cyclooxygenases and lipoxygenases are proinflammatory enzymes; the former affects platelet aggregation, vasoconstriction, vasodilatation and later the development of atherosclerosis. Red wines from Georgia and central and western Europe inhibited cyclooxygenase-1 (COX-1) activity in the range of 63-94%, cyclooxygenase-2 (COX-2) activity in the range of 20-44% (tested at a concentration of 5 mL/L), and 5-lipoxygenase (5-LOX) activity in the range of 72-84% (at a concentration of 18.87 mL/L). White winesinhibited 5-LOX in the range of 41-68% at a concentration of 18.87 mL/L and did not inhibit COX-1 and COX-2. Piceatannol (IC50 = 0.76 mu M) was identified as a strong inhibitor of 5-LOX followed by luteolin (IC50 = 2.25 mu M), quercetin (IC50 = 3.29 mu M), and myricetin (IC50 - 4.02 mu M). trans-Resveratrol was identified as an inhibitor of COX-1 (IC50 - 2.27 mu M) and COX-2 (IC50 - 3.40 mu M). Red wine as a complex mixture is a powerful inhibitor of COX-1, COX-2, and 5-LOX, the enzymes

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GM - Food industry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Mediators of Inflammation

ISSN

0962-9351

e-ISSN

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Volume of the periodical

2014

Issue of the periodical within the volume

UNSP 178931

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

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UT code for WoS article

000337438400001

EID of the result in the Scopus database

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