Myrica rubra leaves as a potential source of a dual 5-LOX/COX inhibitor
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F17%3A00474824" target="_blank" >RIV/61389030:_____/17:00474824 - isvavai.cz</a>
Alternative codes found
RIV/60460709:41210/17:72094
Result on the web
<a href="http://dx.doi.org/10.1080/09540105.2016.1272554" target="_blank" >http://dx.doi.org/10.1080/09540105.2016.1272554</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/09540105.2016.1272554" target="_blank" >10.1080/09540105.2016.1272554</a>
Alternative languages
Result language
angličtina
Original language name
Myrica rubra leaves as a potential source of a dual 5-LOX/COX inhibitor
Original language description
Myrica rubra Sieb. et Zucc. is a valuable fruit tree that is used in Chinese, Japanese and Taiwanese traditional medicine. We investigated the anti-inflammatory activity of M. rubra leaves extracted with four different solvents. Total phenolics were determined using the Folin-Ciocalteu method. Extracts were investigated for their inhibitory activity toward the pro-inflammatory enzymes cyclooxygenase-1 and2 (COX-1, COX-2) and 5-lipoxygenase (5-LOX). The ethanol extract of M. rubra leaves demonstrated a strong inhibition of prostaglandin E-2 (PGE(2)) biosynthesis catalyzed by both COX-1 (93.42%) and COX-2 (75.71%) and leukotriene B-4 (LTB4) formation catalyzed by 5-LOX (82.72%). Further we identified selective COX-1 inhibition by the n-butanol and aqueous fractions of the ethanol extract (with an IC50 for COX-1 inhibition of 1.07 and 0.71 mu gmL(-1) (,) respectively) and dual 5-LOX/COX inhibition by the ethyl acetate fraction (with an IC50 of 3.29 for COX-1, 2.54 for COX-2 and 8.30 mu gmL(-1) for 5-LOX).
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Food and Agricultural Immunology
ISSN
0954-0105
e-ISSN
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Volume of the periodical
28
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
343-353
UT code for WoS article
000394647700015
EID of the result in the Scopus database
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