Effect of Dietary Stilbenes on 5-Lipoxygenase and Cyclooxygenases Activities In Vitro
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F15%3A00446931" target="_blank" >RIV/61389030:_____/15:00446931 - isvavai.cz</a>
Alternative codes found
RIV/60460709:41340/15:67484
Result on the web
<a href="http://dx.doi.org/10.1080/10942912.2014.903416" target="_blank" >http://dx.doi.org/10.1080/10942912.2014.903416</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/10942912.2014.903416" target="_blank" >10.1080/10942912.2014.903416</a>
Alternative languages
Result language
angličtina
Original language name
Effect of Dietary Stilbenes on 5-Lipoxygenase and Cyclooxygenases Activities In Vitro
Original language description
Stilbenes contained in various foods are associated with health beneficial effects. In this study six natural and one synthetic stilbene were tested for their potential to regulate the activity of lipoxygenase and cyclooxygenase in vitro. The most potentinhibitor of 5-lipoxygenase was pterostilbene (IC50 = 9.32 mu M), whereas the strongest inhibitor of cyclooxygenase-1 and cyclooxygenase-2 was pinostilbene (IC50s = 1.90 and 0.35 mu M, respectively). Pterostilbene (IC50s = 11.70 and 27.04 mu M for cyclooxygenase-1 and cyclooxygenase-2, respectively) and oxyresveratrol (IC50s = 18.49; 2.79 and 14.71 mu M for 5-lipoxygenase, cyclooxygenase-1, and cyclooxygenase-2, respectively) were capable to inhibit catalytic activity of all three tested enzymes. Isorhapontigenin (IC50s = 8.81 and 24.00 mu M for cyclooxygenase-1 and cyclooxygenase-2, respectively) and rhapontigenin (IC50s = 24.55 and 36.12 mu M for cyclooxygenase-1 and cyclooxygenase-2, respectively) were only moderate or weak inhibito
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EI - Biotechnology and bionics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LH12164" target="_blank" >LH12164: Production of Dendrobium candidum biomass in vitro and study its biological activity</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Food Properties
ISSN
1094-2912
e-ISSN
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Volume of the periodical
18
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
1471-1477
UT code for WoS article
000355244800009
EID of the result in the Scopus database
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