Carvacrol as the inhibitor of cyclooxygenase-1 and -2, the key enzymes of prostaglandin biosynthesis: in vitro assays

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41610%2F06%3A17515" target="_blank" >RIV/60460709:41610/06:17515 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Carvacrol as the inhibitor of cyclooxygenase-1 and -2, the key enzymes of prostaglandin biosynthesis: in vitro assays

Original language description

Carvacrol is a phenolic monoterpene which is one of the most abundant constituents in essential oil of many aromatic plants such as oregano (Origanum vulgare L.), savory (Satureja thymbra L.), thyme (Thymus vulgaris L.), rosemary (Rosmarinus officinalisL.), fennel (Foeniculum vulgare L.) and black cumin (Nigella sativa L.). These species are widely used in traditional medicine against various microbial diseases and gastrointestinal and inflammatory disorders. Antimicrobial, antiangiogenic, antioxidative and analgesic activity of carvacrol was also confirmed by recent studies [1, 2]. Carvacrol is closely related to other phenolic monoterpenes as thymol or eugenol, which anti-inflammatory effects have been published [3]. The inhibition of cyclooxygenase-1 (COX-1) and ?2 (COX-2) enzymatic activities by carvacrol is reported here. The anti-inflammatory assay was based on inhibition of activity of COX-1 and ?2, which catalyzes prostaglandin biosynthesis from [14C] radioactive arachidonic a

Czech name

Karvakrol jako inhibitor cyklooxygenazy-1 a -2 klíčových enzymů biosyntézy prostaglandínů: in vitro test

Czech description

Carvacrol is a phenolic monoterpene which is one of the most abundant constituents in essential oil of many aromatic plants such as oregano (Origanum vulgare L.), savory (Satureja thymbra L.), thyme (Thymus vulgaris L.), rosemary (Rosmarinus officinalisL.), fennel (Foeniculum vulgare L.) and black cumin (Nigella sativa L.). These species are widely used in traditional medicine against various microbial diseases and gastrointestinal and inflammatory disorders. Antimicrobial, antiangiogenic, antioxidative and analgesic activity of carvacrol was also confirmed by recent studies [1, 2]. Carvacrol is closely related to other phenolic monoterpenes as thymol or eugenol, which anti-inflammatory effects have been published [3]. The inhibition of cyclooxygenase-1 (COX-1) and ?2 (COX-2) enzymatic activities by carvacrol is reported here. The anti-inflammatory assay was based on inhibition of activity of COX-1 and ?2, which catalyzes prostaglandin biosynthesis from [14C] radioactive arachidonic a

Type

D - Article in proceedings

CEP classification

GM - Food industry

OECD FORD branch

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Project

<a href="/en/project/GA525%2F06%2F0864" target="_blank" >GA525/06/0864: Revision of taxonomical distribution of isoflavonoids</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2006

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Planta Medica: 54th Congress on Medicinal Plant Research

ISBN

ISSN 0032-0943

ISSN

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e-ISSN

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Number of pages

1

Pages from-to

1010-1010

Publisher name

Georg Thieme Verlag KG, Stuttgard

Place of publication

Stuttgart, Germany

Event location

Helsinki, Finland

Event date

Sep 29, 2006

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

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