Systemic administration of D2 antagonist raclopride inhibits CYP1A2 in the rat model of isolated perfused liver

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F11%3A00052906" target="_blank" >RIV/00216224:14740/11:00052906 - isvavai.cz</a>

Result on the web

<a href="http://www.rediviva.sav.sk/53i1/32.pdf" target="_blank" >http://www.rediviva.sav.sk/53i1/32.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Systemic administration of D2 antagonist raclopride inhibits CYP1A2 in the rat model of isolated perfused liver

Original language description

Our study addressed whether systemic administration of raclopride (D2 receptor antagonist) may influence the metabolic activity of rat CYP1A2, CYP2C6/11 or CYP2D2 in the model of isolated perfused liver. It was taken into consideration that CYP2C6/11 isa rat orthologue of human CYP2C9 (Matuskova et al 2009), CYP2D1 is rat orthologue of human CYP2D6 (Soucek &amp; Gut 1992). The most used marker of CYP2D6 dextromethorphan is metabolized by CYP2D2 in rats (Kobayashi et al 2002). The model of isolated perfused rat liver was selected because it reflects most of physiological and biochemical linkages in the liver-mediated metabolism of xenobiotics

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Activitas Nervosa Superior Rediviva

ISSN

1337-933X

e-ISSN

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Volume of the periodical

53

Issue of the periodical within the volume

1

Country of publishing house

SK - SLOVAKIA

Number of pages

3

Pages from-to

32-34

UT code for WoS article

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EID of the result in the Scopus database

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