Role of Everlasting Triplet Expansions in Protein Evolution

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F11%3A00054893" target="_blank" >RIV/00216224:14740/11:00054893 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s00239-010-9425-0" target="_blank" >http://dx.doi.org/10.1007/s00239-010-9425-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00239-010-9425-0" target="_blank" >10.1007/s00239-010-9425-0</a>

Result language
angličtina
Original language name
Role of Everlasting Triplet Expansions in Protein Evolution
Original language description
Analysis of occurrence of simple amino acid repeats in large ensemble of prokaryotic and eukaryotic sequences reveals that nearly all amino acids found in the repeats belong to those which have in their codon repertoires aggressively expanding triplets,all of three known pathologically expanding classes GCU (GCU, CUG, UGC, AGC, GCA, CAG), GCC (GCC, CCG, CGC, GGC, GCG, CGG), and AAG (AAG, AGA, GAA, CTT, TTC, TCT).The spontaneous expansions continued to occur all the way during evolution, leaving their footprints in the protein-coding sequences as still visible simple amino acid repeats, as preferred triplets encoding the repeats, and as preferred codons in the codon usage tables.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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