HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F12%3A00057107" target="_blank" >RIV/00216224:14740/12:00057107 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/12:00382635
Result on the web
<a href="http://link.springer.com/article/10.1007%2Fs00412-012-0373-x" target="_blank" >http://link.springer.com/article/10.1007%2Fs00412-012-0373-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00412-012-0373-x" target="_blank" >10.1007/s00412-012-0373-x</a>

Result language
angličtina
Original language name
HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction
Original language description
Telomere repeats are added onto chromosome ends by telomerase, consisting of two main core components: a catalytic protein subunit (telomerase reverse trancriptase, TERT), and an RNA subunit (telomerase RNA, TR). The ability of HMGB1 to modulate cellularactivity of telomerase and to maintain telomere integrity can help to understand some aspects of the protein involvement in chromosome stability and cancer.
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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