Formamide-Based Prebiotic Synthesis of Nucleobases: A Kinetically Accessible Reaction Route
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F12%3A00057255" target="_blank" >RIV/00216224:14740/12:00057255 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/12:00379302
Result on the web
<a href="http://pubs.acs.org/doi/full/10.1021/jp209886b" target="_blank" >http://pubs.acs.org/doi/full/10.1021/jp209886b</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/jp209886b" target="_blank" >10.1021/jp209886b</a>
Alternative languages
Result language
angličtina
Original language name
Formamide-Based Prebiotic Synthesis of Nucleobases: A Kinetically Accessible Reaction Route
Original language description
Synthesis of nucleobases in nonaqueous environments is an alternative way for the emergence of terrestrial life, which could solve the fundamental problem connected to the hydrolytic instability of nucleic acid components in an aqueous environment. In this contribution, we present a plausible reaction route for the prebiotic synthesis of nucleobases in formamide, which does not require participation of the formamide trimer and aminoimidazole-carbonitrile intermediates. The computed activation energy ofthe proposed pathway is noticeably higher than that of the HCN-based synthetic route, but it is still feasible under the experimental conditions of the Saladino synthesis. We show that, albeit both the pyrimidine and purine ring formation utilizes the undissociated form of formamide, the dehydration product of formamide, HCN, may also play a key role in the mechanism. The rate determining step of the entire reaction path is the cyclization of the diaza-pentanimine precursor.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The Journal of Physical Chemistry A
ISSN
1089-5639
e-ISSN
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Volume of the periodical
116
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
720-726
UT code for WoS article
000298978000076
EID of the result in the Scopus database
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