The effects of methamphetamine self-administration on behavioural sensitization in the olfactory bulbectomy rat model of depression
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F12%3A00059286" target="_blank" >RIV/00216224:14740/12:00059286 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16170/12:43870308
Result on the web
<a href="http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8704767" target="_blank" >http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8704767</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1017/S1461145711001684" target="_blank" >10.1017/S1461145711001684</a>
Alternative languages
Result language
angličtina
Original language name
The effects of methamphetamine self-administration on behavioural sensitization in the olfactory bulbectomy rat model of depression
Original language description
Depression is frequently comorbid with a drug addiction and may seriously complicate its treatment. Currently, there is no routinely used animal model to investigate this comorbidity. In this study the effect of repeated administration of methamphetamineon i.v. drug self-administration in an olfactory bulbectomy model of depression in rats was investigated in order to propose and validate a rat model of comorbid depression and addiction. Male Wistar rats were either olfactory-bulbectomized (OBX) or sham-operated. They subsequently underwent a methamphetamine sensitization regime, which consisted of daily i.p. injections of methamphetamine for a 14-d period; controls received Sal injections at the same frequency. The i.v. self-administration of methamphetamine (0.08 mg/kg in one infusion) paradigm on a fixed ratio schedule of reinforcement was performed using operant chambers.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The International Journal of Neuropsychopharmacology
ISSN
1461-1457
e-ISSN
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Volume of the periodical
15
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
1503-1511
UT code for WoS article
000309740200011
EID of the result in the Scopus database
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