The effect of memantine on behavioural sensitisation to methamphetamine in mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F12%3A00061670" target="_blank" >RIV/00216224:14740/12:00061670 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16170/12:43870988

Result on the web

<a href="http://vri.cz/docs/vetmed/57-10-543.pdf" target="_blank" >http://vri.cz/docs/vetmed/57-10-543.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The effect of memantine on behavioural sensitisation to methamphetamine in mice

Original language description

After repeated administration the psychostimulant methamphetamine (Met) produces a substantial increase in behavioural responses, which is termed behavioural sensitisation. Many studies have reported that N-methyl-d-aspartate (NMDA) receptors play an important role in the development and expression of behavioural sensitisation. Memantine (Mem) is used particularly for the treatment of Alzheimer?s disease and acts as a non-competitive NMDA glutamate receptor antagonist, possessing a variety of psychotropic effects. For example, there are studies indicating that memantine prevents the expression of withdrawal symptoms in mice and causes reversal of opioid dependence. Although not all pharmacological mechanisms of memantine have been clarified yet, it isknown that memantine inhibits NMDA receptor inward currents. Thus, the present study was designed to assess whether memantine would influence behavioural sensitisation to the stimulatory effects of methamphetamine on mouse locomotion.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Veterinarni Medicina

ISSN

0375-8427

e-ISSN

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Volume of the periodical

57

Issue of the periodical within the volume

10

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

8

Pages from-to

543-550

UT code for WoS article

000311988200004

EID of the result in the Scopus database

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