The effect of sertindole on behavioural sensitisation to methamphetamine in mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F12%3A00063522" target="_blank" >RIV/00216224:14740/12:00063522 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16170/12:43870989

Result on the web

<a href="http://vri.cz/docs/vetmed/57-11-603.pdf" target="_blank" >http://vri.cz/docs/vetmed/57-11-603.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The effect of sertindole on behavioural sensitisation to methamphetamine in mice

Original language description

Similarly to various other addictive substances, Methamphetamine (Met) produces, following repeated application, a strong increase in behavioural responses (particularly locomotor behaviour), a phenomenon termed behavioural sensitisation. In our previousstudies we tested the effects of various psychotropic drugs on behavioural sensitisation to Met, particularly the effects of cannabinoid receptor ligands with different intrinsic activities and felbamate and memantine, antagonists of N-methyl-d-aspartate (NMDA) receptors. In the present study we investigated the influence of the antipsychotic drug sertindole (Srt) on sensitisation to the effects of Met on mouse locomotor behaviour in the Open field test. Male mice were randomly divided into 4 groups and were administered drugs seven times (from the 7th to 13th day of the experiment) as follows: (a) n1, 2: Met at doses of 2.5 mg/kg/day; (b) n3: Met + Srt at doses of 2.5 mg/kg/day + 10.0 mg/kg/day; (c) n4: Srt at a dose of 10.0 mg/kg/day

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Veterinarni Medicina

ISSN

0375-8427

e-ISSN

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Volume of the periodical

57

Issue of the periodical within the volume

11

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

603-609

UT code for WoS article

000313211200006

EID of the result in the Scopus database

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