Kinetic Study of Metal Complexes with Tetraazamacrocyclic Ligands with Carboxylate/Phosphonate Pendant Arms

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F12%3A00062140" target="_blank" >RIV/00216224:14740/12:00062140 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Kinetic Study of Metal Complexes with Tetraazamacrocyclic Ligands with Carboxylate/Phosphonate Pendant Arms
Original language description
Ln(III) and Cu(II) complexes are utilized in medicine and preclinical research as magnetic resonance, optical or nuclear probes for diagnostics and/or for cancer treatment. For biomedical applications, such complexes should exhibit a high thermodynamic stability as well as kinetic inertness under physiological conditions. Thus, knowledge of their thermodynamic/kinetic properties (e.g. dissociation rate constants for an estimation of kinetic inertness) is important to evaluate their use in these applications. Here, thermodynamic and kinetic properties of Cu(II), Ce(III) and Eu(III) complexes with macrocyclic cyclen-based ligands where acetate pendant arms were substituted by phosphonates (H4dota, H5do3ap, trans-H6do2a2p, H7doa3p, H8dotp) [1?4] are presented. In addition, the influence of substitution of one acetate/phosphonate of (H2do2a/H3do3a/H4dota/H5do3ap derivatives) and/or all phosphonate pendant arms (H8dotp derivatives) was also studied [5-7].
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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