TRAMP Stimulation of Exosome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F12%3A00065939" target="_blank" >RIV/00216224:14740/12:00065939 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/B978-0-12-404740-2.00004-5" target="_blank" >http://dx.doi.org/10.1016/B978-0-12-404740-2.00004-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/B978-0-12-404740-2.00004-5" target="_blank" >10.1016/B978-0-12-404740-2.00004-5</a>
Alternative languages
Result language
angličtina
Original language name
TRAMP Stimulation of Exosome
Original language description
In order to control and/or enhance the specificity and activity of nuclear surveillance and degradation, exosomes cooperate with the polyadenylation complex called TRAMP. Two forms of TRAMP operate in budding yeast, TRAMP4 and TRAMP5. They oligoadenylatedefective or precursor forms of RNAs and promote trimming or complete degradation by exosomes. TRAMPs target a wide variety of nuclear transcripts. The known substrates include the noncoding RNAs originating from pervasive transcription from diverse parts of the yeast genome. Although TRAMP and exosomes can be triggered to a subset of their targets via the RNA-binding complex Nrd1, it is still not completely understood how TRAMP recognizes other aberrant RNAs. The existence of TRAMP-like complexes in other organisms indicates the importance of nuclear surveillance for general cell biology. In this chapter, we review the current understanding of TRAMP function and substrate repertoire.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
The Enzymes: Eukaryotic RNases and their Partners in RNA Degradation and Biogenesis, Part A
ISBN
9780124047402
Number of pages of the result
19
Pages from-to
77-95
Number of pages of the book
265
Publisher name
Elsevier Inc.
Place of publication
Burlington
UT code for WoS chapter
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