Analysis of selected miRNAs in glioblastoma stem cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F13%3A00065595" target="_blank" >RIV/00216224:14740/13:00065595 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Analysis of selected miRNAs in glioblastoma stem cells
Original language description
Glioblastoma multiforme (GBM) is the most frequent malignant brain tumor characterized by very poor prognosis. Despite a treatment based on maximal surgical resection followed by concomitant chemoradiotherapy with temozolomide and adjuvant temozolomide,the median of overall survival is less than 15 months from diagnosis. This is caused by a high resistance to the therapy that is attributed to small subpopulation of glioblastoma stem cells. Similar like non-cancer neuronal stem cells, they express markers of undifferentiated stem cell such as CD133. MicroRNAs are small, non-coding RNAs that function as post-transcription regulators of gene expression. Therefore, they play also key role in maintaining of glioblastoma stem cells phenotype including a resistance to the chemoradiotherapy.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů