Fast sampling mode for MALDI TOF mass spectrometry imaging using scanning desorption laser beam

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F13%3A00066034" target="_blank" >RIV/00216224:14740/13:00066034 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Fast sampling mode for MALDI TOF mass spectrometry imaging using scanning desorption laser beam
Original language description
Successful application of matrix-assisted laser desorption/ionization time-of-flight (MALDI TOF) mass spectrometry imaging (MSI) at biomarker discovery, drug and metabolites distribution analysis and neural network studies provided this technique with aninfluential position among imaging techniques. Using label-free approach, MSI is able to detect and localize a wide range of ionizable substances in biological tissues. A disadvantage of this technique is speed of the analysis. Since the very beginning,a single acquisition of a high-resolution MS image could take even days. Recent commercial mass spectrometers employing high-repetition rate solid-state desorption lasers significantly improved MALDI MSI throughput, but the analysis time is still in theorder of hours. Here we introduce a novel sampling approach taking advantage of incorporation of a high-speed precision scanning mirror redirecting the desorption laser beam across the imaged sample area.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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