MiR-190 leads to aggressive phenotype of neuroblastoma through indirect activation of TrkB pathway

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F13%3A00067593" target="_blank" >RIV/00216224:14740/13:00067593 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0306987712005142#" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0306987712005142#</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.mehy.2012.11.033" target="_blank" >10.1016/j.mehy.2012.11.033</a>

Result language
angličtina
Original language name
MiR-190 leads to aggressive phenotype of neuroblastoma through indirect activation of TrkB pathway
Original language description
Almost one third of all children with advanced stage neuroblastoma (NBL) is incurable. TrkB expressing NBLs frequently have MYCN amplification and are very aggressive and often fatal tumors. Little is known about the mechanisms by which TrkB is regulated. Here, we suggest new mechanism by which TrkB could be regulated. We hypothesize that miR-190 leads to aggressive phenotype of NBL through indirect activation of TrkB pathway, whereas NEUROD1 presents link between miR-190 and TrkB pathway.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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