Subunit Folds and Maturation Pathway of a dsRNA Virus Capsid
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F13%3A00069193" target="_blank" >RIV/00216224:14740/13:00069193 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/13:00396078
Result on the web
<a href="http://www.ncbi.nlm.nih.gov/pubmed/23891288" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/23891288</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.str.2013.06.007" target="_blank" >10.1016/j.str.2013.06.007</a>
Alternative languages
Result language
angličtina
Original language name
Subunit Folds and Maturation Pathway of a dsRNA Virus Capsid
Original language description
The cystovirus phi 6 shares several distinct features with other double-stranded RNA (dsRNA) viruses, including the human pathogen, rotavirus: segmented genomes, nonequivalent packing of 120 subunits in its icosahedral capsid, and capsids as compartmentsfor transcription and replication. phi 6 assembles as a dodecahedral procapsid that undergoes major conformational changes as it matures into the spherical capsid. We determined the crystal structure of the capsid protein, P1, revealing a flattened trapezoid subunit with an alpha-helical fold. We also solved the procapsid with cryo-electron microscopy to comparable resolution. Fitting the crystal structure into the procapsid disclosed substantial conformational differences between the two P1 conformers. Maturation via two intermediate states involves remodeling on a similar scale, besides huge rigid-body rotations.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Structure
ISSN
0969-2126
e-ISSN
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Volume of the periodical
21
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
1374-1383
UT code for WoS article
000322927900013
EID of the result in the Scopus database
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