Structural dynamics of possible late-stage intermediates in folding of quadruplex DNA studied by molecular simulations

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F13%3A00069533" target="_blank" >RIV/00216224:14740/13:00069533 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/13:00422264

Result on the web

<a href="http://nar.oxfordjournals.org/content/41/14/7128" target="_blank" >http://nar.oxfordjournals.org/content/41/14/7128</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/nar/gkt412" target="_blank" >10.1093/nar/gkt412</a>

Result language

angličtina

Original language name

Structural dynamics of possible late-stage intermediates in folding of quadruplex DNA studied by molecular simulations

Original language description

Explicit solvent molecular dynamics simulations have been used to complement preceding experimental and computational studies of folding of guanine quadruplexes (G-DNA). We initiate early stages of unfolding of several G-DNAs by simulating them under no-salt conditions and then try to fold them back using standard excess salt simulations. There is a significant difference between G-DNAs with all-anti parallel stranded stems and those with stems containing mixtures of syn and anti guanosines. The most natural rearrangement for all-anti stems is a vertical mutual slippage of the strands. This leads to stems with reduced numbers of tetrads during unfolding and a reduction of strand slippage during refolding. The presence of syn nucleotides prevents mutualstrand slippage; therefore, the antiparallel and hybrid quadruplexes initiate unfolding via separation of the individual strands.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CF - Physical chemistry and theoretical chemistry

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nucleic Acids Research

ISSN

0305-1048

e-ISSN

—

Volume of the periodical

41

Issue of the periodical within the volume

14

Country of publishing house

GB - UNITED KINGDOM

Number of pages

16

Pages from-to

7128-7143

UT code for WoS article

000323050700037

EID of the result in the Scopus database

—