Explaining the varied glycosidic conformational, G-tract length and sequence preferences for anti-parallel G-quadruplexes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F11%3A00365887" target="_blank" >RIV/68081707:_____/11:00365887 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1093/nar/gkr031" target="_blank" >http://dx.doi.org/10.1093/nar/gkr031</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/nar/gkr031" target="_blank" >10.1093/nar/gkr031</a>

Result language
angličtina
Original language name
Explaining the varied glycosidic conformational, G-tract length and sequence preferences for anti-parallel G-quadruplexes
Original language description
Guanine-rich DNA sequences tend to form four-stranded G-quadruplex structures. Characteristic glycosidic conformational patterns along the G-strands, such as the 50-syn-anti-syn-anti pattern observed with the Oxytricha nova telomeric G-quadruplexes, havebeen well documented. However, an explanation for these featured glycosidic patterns has not emerged. This work presents MD simulation and free energetic analyses for simplified two-quartet [d(GG)]4 models and suggests that the four base pair step patterns show quite different relative stabilities: syn-anti>anti-anti>anti-syn->syn-syn.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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