Antigen selection in B-cell lymphomas-Tracing the evidence

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F13%3A00072727" target="_blank" >RIV/00216224:14740/13:00072727 - isvavai.cz</a>
Result on the web
<a href="http://ac.els-cdn.com/S1044579X1300076X/1-s2.0-S1044579X1300076X-main.pdf?_tid=53d1b2dc-bfba-11e3-91ac-00000aab0f6b&acdnat=1397029454_a5ad89568b55191984c5a6ad89549a75" target="_blank" >http://ac.els-cdn.com/S1044579X1300076X/1-s2.0-S1044579X1300076X-main.pdf?_tid=53d1b2dc-bfba-11e3-91ac-00000aab0f6b&acdnat=1397029454_a5ad89568b55191984c5a6ad89549a75</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.semcancer.2013.07.006" target="_blank" >10.1016/j.semcancer.2013.07.006</a>

Result language
angličtina
Original language name
Antigen selection in B-cell lymphomas-Tracing the evidence
Original language description
While signaling through the B cell receptor (BcR) facilitates B cell development and maintenance, it also carries intertwined risks for the development of lymphomas since malignant B cells can exploit these pathways in order to trigger and fuel clonal expansion. This corruption of the normal B cell response to antigens, leading to sustained BcR signaling, has given great impulse to investigate in detail the role of antigen in lymphomas. Suffice it to conclude from such studies, largely immunogenetics based, that the evidence implicating antigens (exogenous or self) in lymphoma development is substantial and that lymphomagenesis is functionally driven and dynamic, rather than a simple stochastic process. As the paradigm of antigen-driven lymphoma evolves, further investigation will be paramount to the identification of the inciting agent(s) that may be responsible for immunoproliferative neoplasms and also for the development of therapeutic agents targeting effectors of the BcR signalin
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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