B-cell receptor signalling and its crosstalk with other pathways in normal and malignant cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F15%3A00082256" target="_blank" >RIV/00216224:14740/15:00082256 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/15:00063170
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1111/ejh.12427/pdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/ejh.12427/pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/ejh.12427" target="_blank" >10.1111/ejh.12427</a>
Alternative languages
Result language
angličtina
Original language name
B-cell receptor signalling and its crosstalk with other pathways in normal and malignant cells
Original language description
The physiology of B cells is intimately connected with the function of their B-cell receptor (BCR). B-cell lymphomas frequently (dys)regulate BCR signalling and thus take advantage of this pre-existing pathway for B-cell proliferation and survival. Thishas recently been underscored by clinical trials demonstrating that small molecules (fosfamatinib, ibrutinib, idelalisib) inhibiting BCR-associated kinases (SYK, BTK, PI3K) have an encouraging clinical effect. Here we describe the current knowledge of the specific aspects of BCR signalling in diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, chronic lymphocytic leukaemia (CLL) and normal B cells. Multiple factors can contribute to BCR pathway (dys)regulation in these malignancies and the activation of 'chronic' or 'tonic' BCR signalling.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Haematology
ISSN
0902-4441
e-ISSN
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Volume of the periodical
94
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
193-205
UT code for WoS article
000350357900003
EID of the result in the Scopus database
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