Microenvironmental interactions in B cell leukemias and lymphomas: implications for targeted therapy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F21%3A00075121" target="_blank" >RIV/65269705:_____/21:00075121 - isvavai.cz</a>
Result on the web
<a href="https://www.img.cas.cz/files/2021/09/PhD-Conference-2021-Abstract-Book.pdf" target="_blank" >https://www.img.cas.cz/files/2021/09/PhD-Conference-2021-Abstract-Book.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Microenvironmental interactions in B cell leukemias and lymphomas: implications for targeted therapy
Original language description
The biology of multiple mature B cell leukemias and lymphomas largely depends on microenvironmental interactions that provide pro-survival and pro-proliferative signals. B Cell Receptor (BCR) signalling plays a pivotal role and this stems from its fundamental importance for the maturation, survival, and proliferation of B cells. B cell malignancies frequently harbor mutations in this pathway or complex non-genetic deregulation of BCR signalling. This is underscored by the remarkable clinical effect of inhibitors targeting BCR-associated kinases BTK and PI3K. Moreover, the differences in BCR signalling propensity contribute to variable clinical behavior of B cell lymphomas.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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