Suppression of the LMP2A target gene, EGR-1, protects Hodgkin's lymphoma cells from entry to the EBV lytic cycle

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33144861" target="_blank" >RIV/61989592:15110/13:33144861 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/path.4198" target="_blank" >http://dx.doi.org/10.1002/path.4198</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/path.4198" target="_blank" >10.1002/path.4198</a>

Result language
angličtina
Original language name
Suppression of the LMP2A target gene, EGR-1, protects Hodgkin's lymphoma cells from entry to the EBV lytic cycle
Original language description
Hodgkin's lymphoma is unusual among B cell lymphomas, in so far as the malignant Hodgkin/Reed - Sternberg (HRS) cells lack a functional B cell receptor (BCR), as well as many of the required downstream signalling components. In Epstein-Barr virus (EBV) -positive cases of Hodgkin's lymphoma, HRS cells express the viral latent membrane proteins (LMP)-1 and -2A. LMP2A is throught to contribute to the pathogenesis of Hodhkin's lymphoma by providing a surrogate BCR-like survival signal.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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