Telomere repeat binding proteins are functional components of Arabidopsis telomeres and interact with telomerase

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F14%3A00073912" target="_blank" >RIV/00216224:14740/14:00073912 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/14:00427960

Result on the web

<a href="http://onlinelibrary.wiley.com/doi/10.1111/tpj.12428/epdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/tpj.12428/epdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/tpj.12428" target="_blank" >10.1111/tpj.12428</a>

Result language

angličtina

Original language name

Telomere repeat binding proteins are functional components of Arabidopsis telomeres and interact with telomerase

Original language description

Although telomere-binding proteins constitute an essential part of telomeres, in vivo data indicating the existence of a structure similar to mammalian shelterin complex in plants are limited. Partial characterization of a number of candidate proteins has not identified true components of plant shelterin or elucidated their functional mechanisms. Telomere repeat binding (TRB) proteins from Arabidopsis thaliana bind plant telomeric repeats through a Myb domain of the telobox type in vitro, and have beenshown to interact with POT1b (Protection of telomeres 1). Here we demonstrate co-localization of TRB1 protein with telomeres in situ using fluorescence microscopy, as well as in vivo interaction using chromatin immunoprecipitation. Classification of theTRB1 protein as a component of plant telomeres is further confirmed by the observation of shortening of telomeres in knockout mutants of the trb1 gene. Moreover, TRB proteins physically interact with plant telomerase catalytic subunits.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

The Plant Journal

ISSN

0960-7412

e-ISSN

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Volume of the periodical

77

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

770-781

UT code for WoS article

000331848700010

EID of the result in the Scopus database

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