Telomere binding protein TRB1 is associated with promoters of translation machinery genes in vivo

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F16%3A00456328" target="_blank" >RIV/68081707:_____/16:00456328 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/16:00088124
Result on the web
<a href="http://dx.doi.org/10.1007/s11103-015-0409-8" target="_blank" >http://dx.doi.org/10.1007/s11103-015-0409-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11103-015-0409-8" target="_blank" >10.1007/s11103-015-0409-8</a>

Result language
angličtina
Original language name
Telomere binding protein TRB1 is associated with promoters of translation machinery genes in vivo
Original language description
Recently we characterised TRB1, a protein from a single-myb-histone family, as a structural and functional component of telomeres in Arabidopsis thaliana. TRB proteins, besides their ability to bind specifically to telomeric DNA using their N-terminallypositioned myb-like domain of the same type as in human shelterin proteins TRF1 or TRF2, also possess a histone-like domain which is involved in protein-protein interactions e.g., with POT1b. Here we set out to investigate the genome-wide localization pattern of TRB1 to reveal its preferential sites of binding to chromatin in vivo and its potential functional roles in the genome-wide context. Our results demonstrate that TRB1 is preferentially associated with promoter regions of genes involved in ribosome biogenesis, in addition to its roles at telomeres. This preference coincides with the frequent occurrence of telobox motifs in the upstream regions of genes in this category, but it is not restricted to the presence of a telobox. We co
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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