Holokinetic centromeres and efficient telomere healing enable rapid karyotype evolution

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F15%3A00081618" target="_blank" >RIV/00216224:14740/15:00081618 - isvavai.cz</a>
Result on the web
<a href="http://download.springer.com/static/pdf/859/art%253A10.1007%252Fs00412-015-0524-y.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs00412-015-0524-y&token2=exp=1456303136~acl=%2Fstatic%2Fpdf%2F859%2Fart%25253A10.1007%25252Fs00412-015-05" target="_blank" >http://download.springer.com/static/pdf/859/art%253A10.1007%252Fs00412-015-0524-y.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs00412-015-0524-y&token2=exp=1456303136~acl=%2Fstatic%2Fpdf%2F859%2Fart%25253A10.1007%25252Fs00412-015-05</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00412-015-0524-y" target="_blank" >10.1007/s00412-015-0524-y</a>

Result language
angličtina
Original language name
Holokinetic centromeres and efficient telomere healing enable rapid karyotype evolution
Original language description
Species with holocentric chromosomes are often characterized by a rapid karyotype evolution. In contrast to species with monocentric chromosomes where acentric fragments are lost during cell division, breakage of holocentric chromosomes creates fragmentswith normal centromere activity. To decipher the mechanism that allows holocentric species an accelerated karyotype evolution via chromosome breakage, we analyzed the chromosome complements of irradiated Luzula elegans plants. The resulting chromosomalfragments and rearranged chromosomes revealed holocentromere-typical CENH3 and histone H2AThr120ph signals as well as the same mitotic mobility like unfragmented chromosomes. Newly synthesized telomeres at break points become detectable 3 weeks after irradiation. The presence of active telomerase suggests a telomerase-based mechanism of chromosome healing. A successful transmission of holocentric chromosome fragments across different generations was found for most offspring of irradiated
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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