Detailed analysis of therapy-driven clonal evolution of TP53 mutations in chronic lymphocytic leukemia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F15%3A00082241" target="_blank" >RIV/00216224:14740/15:00082241 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/15:00063172
Result on the web
<a href="http://www.nature.com/leu/journal/v29/n4/pdf/leu2014297a.pdf" target="_blank" >http://www.nature.com/leu/journal/v29/n4/pdf/leu2014297a.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/leu.2014.297" target="_blank" >10.1038/leu.2014.297</a>
Alternative languages
Result language
angličtina
Original language name
Detailed analysis of therapy-driven clonal evolution of TP53 mutations in chronic lymphocytic leukemia
Original language description
In chronic lymphocytic leukemia (CLL), the worst prognosis is associated with TP53 defects with the affected patients being potentially directed to alternative treatment. Therapy administration was shown to drive the selection of new TP53 mutations in CLL. Using ultra-deep next-generation sequencing (NGS), we performed a detailed analysis of TP53 mutations' clonal evolution. We retrospectively analyzed samples that were assessed as TP53-wild-type (wt) by FASAY from 20 patients with a new TP53 mutation detected in relapse and 40 patients remaining TP53-wt in relapse. Minor TP53-mutated subclones were disclosed in 18/20 patients experiencing later mutation selection, while only one minor-clone mutation was observed in those patients remaining TP53-wt (n=40).
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Leukemia
ISSN
0887-6924
e-ISSN
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Volume of the periodical
29
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
877-885
UT code for WoS article
000352586700015
EID of the result in the Scopus database
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