2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F15%3A00084725" target="_blank" >RIV/00216224:14740/15:00084725 - isvavai.cz</a>
Result on the web
<a href="http://download.springer.com/static/pdf/322/art%253A10.1007%252Fs00213-015-3917-y.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs00213-015-3917-y&token2=exp=1447855112~acl=%2Fstatic%2Fpdf%2F322%2Fart%25253A10.1007%25252Fs00213-015-39" target="_blank" >http://download.springer.com/static/pdf/322/art%253A10.1007%252Fs00213-015-3917-y.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs00213-015-3917-y&token2=exp=1447855112~acl=%2Fstatic%2Fpdf%2F322%2Fart%25253A10.1007%25252Fs00213-015-39</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00213-015-3917-y" target="_blank" >10.1007/s00213-015-3917-y</a>

Result language
angličtina
Original language name
2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons
Original language description
The contribution of two major endocannabinoids, 2-arachidonoylglycerol (2-AG) and anandamide (AEA), in the regulation of fear expression is still unknown. We analyzed the role of different players of the endocannabinoid system on the expression of a strong auditory-cued fear memory in male mice by pharmacological means. The cannabinoid receptor type 1 (CB1) antagonist SR141716 (3 mg/kg) caused an increase in conditioned freezing upon repeated tone presentation on three consecutive days. The cannabinoidreceptor type 2 (CB2) antagonist AM630 (3 mg/kg), in contrast, had opposite effects during the first tone presentation, with no effects of the transient receptor potential vanilloid receptor type 1 (TRPV1) antagonist SB366791 (1 and 3 mg/kg). Administration of the CB2 agonist JWH133 (3 mg/kg) failed to affect the acute freezing response, whereas the CB1 agonist CP55,940 (50 mu g/kg) augmented it.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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