Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F15%3A00084826" target="_blank" >RIV/00216224:14740/15:00084826 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/15:00063681
Result on the web
<a href="http://www.bloodjournal.org/content/125/5/856?sso-checked=true" target="_blank" >http://www.bloodjournal.org/content/125/5/856?sso-checked=true</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1182/blood-2014-09-600874" target="_blank" >10.1182/blood-2014-09-600874</a>
Alternative languages
Result language
angličtina
Original language name
Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations
Original language description
An unresolved issue in chronic lymphocytic leukemia (CLL) is whether IGHV3-21 gene usage, in general, or the expression of stereotyped B-cell receptor immunoglobulin defining subset # 2 (IGHV3-21/IGLV3-21), in particular, determines outcome for IGHV3-21-utilizing cases. We reappraised this issue in 8593 CLL patients of whom 437 (5%) used the IGHV3-21 gene with 254/437 (58%) classified as subset # 2. Within subset # 2, immunoglobulin heavy variable (IGHV)-mutated cases predominated, whereas non-subset #2/IGHV3-21 was enriched for IGHV-unmutated cases (P =.002). Subset # 2 exhibited significantly shorter time-to-first-treatment (TTFT) compared with non-subset # 2/IGHV3-21 (22 vs 60 months, P =.001). No such difference was observed between non-subset # 2/IGHV3-21 vs the remaining CLL with similar IGHV mutational status.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Blood
ISSN
0006-4971
e-ISSN
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Volume of the periodical
125
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
856-859
UT code for WoS article
000350814900020
EID of the result in the Scopus database
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