Biological and clinical characteristics of patients with chronic lymphocytic leukemia with the IGHV3-21 and IGHV1-69; analysis of data from a single center
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33154253" target="_blank" >RIV/61989592:15110/15:33154253 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15510/15:33154253 RIV/00098892:_____/15:#0000924
Result on the web
<a href="http://dx.doi.org/10.4149/neo_2015_074" target="_blank" >http://dx.doi.org/10.4149/neo_2015_074</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/neo_2015_074" target="_blank" >10.4149/neo_2015_074</a>
Alternative languages
Result language
angličtina
Original language name
Biological and clinical characteristics of patients with chronic lymphocytic leukemia with the IGHV3-21 and IGHV1-69; analysis of data from a single center
Original language description
This study aimed at mapping the frequency of IGHV3-21 and IGHV1-69 in a group of 417 patients newly diagnosed with chronic lymphocytic leukemia (CLL) and described basic characteristics, cytogenetic abnormalities and prognosis of these patient subgroups.IGHV3-21 was found in 29 patients (7%) and IGHV1-69 in 51 patients (12.4%). The median overall survival (OS) rates were 97 months and 85 months in the IGHV3-21 and IGHV1-69 groups, respectively. In this small group of patients, the study failed to showa difference in OS of IGHV3-21 patients with mutated and unmutated IGHV status (p<0.597). There was also no difference in OS between IGHV3-21 patients with mutated IGHV status and all patients in the group having unmutated IGHV status (p<0.245). On the other hand, patients with IGHV3-21 and the presence of some other adverse prognostic factors (age GREATER-THAN OR EQUAL TO 65 years, lymphocyte count GREATER-THAN OR EQUAL TO 50x109/L, serum thymidine kinase GREATER-THAN OR EQUAL TO 9U/L,
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neoplasma
ISSN
0028-2685
e-ISSN
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Volume of the periodical
62
Issue of the periodical within the volume
4
Country of publishing house
SK - SLOVAKIA
Number of pages
9
Pages from-to
618-626
UT code for WoS article
000362862500013
EID of the result in the Scopus database
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