Familial hypercholesterolaemia: A global call to arms

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F15%3A00085140" target="_blank" >RIV/00216224:14740/15:00085140 - isvavai.cz</a>

Alternative codes found

RIV/00209775:_____/15:#0000333

Result on the web

<a href="http://ac.els-cdn.com/S0021915015301301/1-s2.0-S0021915015301301-main.pdf?_tid=027dcd06-9e40-11e5-83c4-00000aacb361&acdnat=1449643526_89ab5894d31f4df6fd618f2c0be660c6" target="_blank" >http://ac.els-cdn.com/S0021915015301301/1-s2.0-S0021915015301301-main.pdf?_tid=027dcd06-9e40-11e5-83c4-00000aacb361&acdnat=1449643526_89ab5894d31f4df6fd618f2c0be660c6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.atherosclerosis.2015.09.021" target="_blank" >10.1016/j.atherosclerosis.2015.09.021</a>

Result language

angličtina

Original language name

Familial hypercholesterolaemia: A global call to arms

Original language description

Familial Hypercholesterolaemia (FH) is the commonest autosomal co-dominantly inherited condition affecting man. It is caused by mutation in one of three genes, encoding the low-density lipoprotein (LDL) receptor, or the gene for apolipoprotein B (which is the major protein component of the LDL particle), or in the gene coding for PCSK9 (which is involved in the degradation of the LDL-receptor during its cellular recycling). These mutations result in impaired LDL metabolism, leading to life-long elevations in LDL-cholesterol (LDL-C) and development of premature atherosclerotic cardiovascular disease (ASCVD) [1], [2] and [3]. If left untreated, the relative risk of premature coronary artery disease is significantly higher in heterozygous patients than unaffected individuals, with most untreated homozygotes developing ASCVD before the age of 20 and generally not surviving past 30 years [2], [3], [4] and [5].

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Atherosclerosis

ISSN

0021-9150

e-ISSN

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Volume of the periodical

243

Issue of the periodical within the volume

1

Country of publishing house

IE - IRELAND

Number of pages

3

Pages from-to

257-259

UT code for WoS article

000363266000037

EID of the result in the Scopus database

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