MicroRNA-derived network analysis of differentially methylated genes in schizophrenia, implicating GABA receptor B1 [GABBR1] and protein kinase B [AKT1]
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F15%3A00085548" target="_blank" >RIV/00216224:14740/15:00085548 - isvavai.cz</a>
Result on the web
<a href="http://www.biologydirect.com/content/pdf/s13062-015-0089-y.pdf" target="_blank" >http://www.biologydirect.com/content/pdf/s13062-015-0089-y.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s13062-015-0089-y" target="_blank" >10.1186/s13062-015-0089-y</a>
Alternative languages
Result language
angličtina
Original language name
MicroRNA-derived network analysis of differentially methylated genes in schizophrenia, implicating GABA receptor B1 [GABBR1] and protein kinase B [AKT1]
Original language description
Background: While hundreds of genes have been implicated already in the etiology of schizophrenia, the exact cause is not known or the disease is considered multigenic in origin. Recent discoveries of new types of RNAs and the gradual elimination of the"junk DNA" hypothesis refocused the attention on the noncoding part of the human genome. Here we re-analyzed a recent dataset of differentially methylated genes from schizophrenic patients and cross-tabulated them with cis regulatory and repetitive elements and microRNAs known to be involved in schizophrenia. Results: We found that the number of schizophrenia-related (SZ) microRNA targets follows a scale-free distribution with several microRNA hubs and that schizophrenia-related microRNAs with shared targets form a small-world network. The top ten microRNAs with the highest number of SZ gene targets regulate approximately 80 % of all microRNA-regulated genes whereas the top two microRNAs regulate 40-52 % of all such genes.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BIOLOGY DIRECT
ISSN
1745-6150
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
October
Country of publishing house
GB - UNITED KINGDOM
Number of pages
15
Pages from-to
"nestránkováno"
UT code for WoS article
000362802800001
EID of the result in the Scopus database
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