Connecting myelin-related and synaptic dysfunction in schizophrenia with SNP-rich gene expression hubs

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F17%3A00100383" target="_blank" >RIV/00216224:14740/17:00100383 - isvavai.cz</a>

Result on the web

<a href="https://www.nature.com/articles/srep45494.pdf" target="_blank" >https://www.nature.com/articles/srep45494.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/srep45494" target="_blank" >10.1038/srep45494</a>

Result language

angličtina

Original language name

Connecting myelin-related and synaptic dysfunction in schizophrenia with SNP-rich gene expression hubs

Original language description

Combining genome- wide mapping of SNP- rich regions in schizophrenics and gene expression data in all brain compartments across the human life span revealed that genes with promoters most frequently mutated in schizophrenia are expression hubs interacting with far more genes than the rest of the genome.We summed up the differentially methylated " expression neighbors" of genes that fall into one of 108 distinct schizophrenia- associated loci with high number of SNPs.Surprisingly, the number of expression neighbors of the genes in these loci were 35 times higher for the positively correlating genes (32 times higher for the negatively correlating ones) than for the rest of the similar to 16000 genes.While the genes in the 108 loci have little known impact in schizophrenia, we identified many more known schizophrenia- related important genes with a high degree of connectedness (e.g.MOBP, SYNGR1 and DGCR6), validating our approach.Both the most connected positive and negative hubs affected synapse- related genes the most, supporting the synaptic origin of schizophrenia.At least half of the top genes in both the correlating and anti- correlating categories are cancer- related, including oncogenes (RRAS and ALDOA), providing further insight into the observed inverse relationship between the two diseases.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scientific reports

ISSN

2045-2322

e-ISSN

—

Volume of the periodical

7

Issue of the periodical within the volume

April

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

45494

UT code for WoS article

000398602500001

EID of the result in the Scopus database

2-s2.0-85017094765