Multivalent Carbohydrate-based Inhibitors of Lectins
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F16%3A00088173" target="_blank" >RIV/00216224:14740/16:00088173 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Multivalent Carbohydrate-based Inhibitors of Lectins
Original language description
Lectins are sugar-binding proteins of non-immune origin occurring in all organisms and executing various functions. Microbial lectins can recognize carbohydrates on host cells (glycoproteins or glycolipids) and mediate adhesion to host cells or mucosal surfaces. Adhesion is considered to be an important step in the infection development as it protects a pathogen from natural cleansing mechanisms of the host. Consequently, lectins could be significant virulence factors. Therefore, blocking of adhesion could prevent disease development or facilitate treatment. Our most promising results were obtained for L-fucose-specific lectins AFL from A. fumigatus (the most prominent fungal human pathogen causing nosocomial infections) and RSL from R. solanacearum (a dangerous pathogen of important agricultural plants). The inhibition potencies of carbohydrate-based inhibitors with a calixarene core were significantly higher than that of a simple fucose monosaccharide.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů