Cv-IIL: new lectin from human oportunistic pathogen Chromobacterium violaceum

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F05%3A00014124" target="_blank" >RIV/00216224:14310/05:00014124 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Cv-IIL: new lectin from human oportunistic pathogen Chromobacterium violaceum
Original language description
Pathogen adhesion to the host cell surface followed by its colonisation, invasion and infectivity is usually mediated by protein-carbohydrate interactions. Pseudomonas aeruginosa, an opportunistic pathogen responsible for numerous nosocomial infections in immunocopromised patients, produces a variety of carbohydrate-binding proteins that could be involved in host recognition and adhesion. One of them, PA-IIL, is a fucose binding lectin that is closely related to the virulence of the bacterium [1]. Searching in databases for proteins displaying sequence similarities to PA-IIL revealed new homologous proteins in other opportunistic pathogens like Chromobacterium violaceum. Human infection by Ch. violaceum is rare but when it occurs, it is associated withvery high mortality rate [2]. The gene cv1741 coding a hypothetical protein similar to PA-IIL, was cloned and the resulting recombinant protein, CV-IIL, has been expressed in E. coli and purified to homogeneity. Binding affinities of the
Czech name
CV-IIL:nový lektin z lidského podmíněného patogenu Chromobacterium violaceum
Czech description
CV-IIL:nový lektin z lidského podmíněného patogenu Chromobacterium violaceum

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—

Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)