Sructure-function characterisation of a new lectin from Chromobacterium violaceum

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F05%3A00013840" target="_blank" >RIV/00216224:14310/05:00013840 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Sructure-function characterisation of a new lectin from Chromobacterium violaceum

Original language description

Carbohydrates are essential components of life that play crucial role in all organisms. They are very important agent in recognition and signalling ways. Lectin-carbohydrate interactions play a crucial role in many recognition events. Pseudomonas aeruginosa, an opportunistic pathogen responsible for numerous nosocomial infections in immunocopromised patients, produces a variety of carbohydrate-binding proteins that could be involved in host recognition and adhesion. One of them, PA-IIL, is a fucose binding lectin that is closely related to the virulence of the bacterium [1]. Searching in databases for proteins displaying sequence similarities to PA-IIL revealed new homologous proteins in other opportunistic pathogens like Chromobacterium violaceum. Human infection by Ch. violaceum is rare but when it occurs, it is associated with very high mortality rate [2]. In Ch. violaceum genome a hypothetical protein similar to PA-IIL and coded by the gene cv1741 was found. The gene was cloned and

Czech name

Strukturně funkční charakterizace nového lektinu z bakterie Chromobacterium violaceum

Czech description

Carbohydrates are essential components of life that play crucial role in all organisms. They are very important agent in recognition and signalling ways. Lectin-carbohydrate interactions play a crucial role in many recognition events. Pseudomonas aeruginosa, an opportunistic pathogen responsible for numerous nosocomial infections in immunocopromised patients, produces a variety of carbohydrate-binding proteins that could be involved in host recognition and adhesion. One of them, PA-IIL, is a fucose binding lectin that is closely related to the virulence of the bacterium [1]. Searching in databases for proteins displaying sequence similarities to PA-IIL revealed new homologous proteins in other opportunistic pathogens like Chromobacterium violaceum. Human infection by Ch. violaceum is rare but when it occurs, it is associated with very high mortality rate [2]. In Ch. violaceum genome a hypothetical protein similar to PA-IIL and coded by the gene cv1741 was found. The gene was cloned and

Type

D - Article in proceedings

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2005

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

The FEBS Journal

ISBN

1474-3833

ISSN

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e-ISSN

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Number of pages

1

Pages from-to

16

Publisher name

FEBS Congres

Place of publication

Budapest

Event location

Budapest

Event date

Jul 2, 2005

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

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