TDM1 Regulation Determines the Number of Meiotic Divisions

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F16%3A00088769" target="_blank" >RIV/00216224:14740/16:00088769 - isvavai.cz</a>

Result on the web

<a href="http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005856" target="_blank" >http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005856</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pgen.1005856" target="_blank" >10.1371/journal.pgen.1005856</a>

Result language

angličtina

Original language name

TDM1 Regulation Determines the Number of Meiotic Divisions

Original language description

Cell cycle control must be modified at meiosis to allow two divisions to follow a single round of DNA replication, resulting in ploidy reduction. The mechanisms that ensure meiosis termination at the end of the second and not at the end of first division are poorly understood. We show here that Arabidopsis thaliana TDM1, which has been previously shown to be essential for meiotic termination, interacts directly with the Anaphase-Promoting Complex. Further, mutations in TDM1 in a conserved putative Cyclin-Dependant Kinase (CDK) phosphorylation site (T16-P17) dominantly provoked premature meiosis termination after the first division, and the production of diploid spores and gametes. The CDKA; 1-CYCA1.2/TAM complex, which is required to prevent premature meiotic exit, phosphorylated TDM1 at T16 in vitro. Finally, while CYCA1;2/TAM was previously shown to be expressed only at meiosis I, TDM1 is present throughout meiosis.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/GA14-22346S" target="_blank" >GA14-22346S: Dissecting the role of TDM1 in meiotic progression</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLOS GENETICS

ISSN

1553-7404

e-ISSN

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Volume of the periodical

12

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

22

Pages from-to

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UT code for WoS article

000372554100039

EID of the result in the Scopus database

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