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Meiotic exit in Arabidopsis is driven by P-body-mediated inhibition of translation

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F22%3A00127511" target="_blank" >RIV/00216224:14740/22:00127511 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.science.org/doi/10.1126/science.abo0904" target="_blank" >https://www.science.org/doi/10.1126/science.abo0904</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1126/science.abo0904" target="_blank" >10.1126/science.abo0904</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Meiotic exit in Arabidopsis is driven by P-body-mediated inhibition of translation

  • Original language description

    Meiosis, at the transition between diploid and haploid life cycle phases, is accompanied by reprograming of cell division machinery and followed by a transition back to mitosis. We show that, in Arabidopsis, this transition is driven by inhibition of translation, achieved by a mechanism that involves processing bodies (P-bodies). During the second meiotic division, the meiosis-specific protein THREE-DIVISION MUTANT 1 (TDM1) is incorporated into P-bodies through interaction with SUPPRESSOR WITH MORPHOGENETIC EFFECTS ON GENITALIA 7 (SMG7). TDM1 attracts eIF4F, the main translation initiation complex, temporarily sequestering it in P-bodies and inhibiting translation. The failure of tdm1 mutants to terminate meiosis can be overcome by chemical inhibition of translation. We propose that TDM1-containing P-bodies down-regulate expression of meiotic transcripts to facilitate transition of cell fates to postmeiotic gametophyte differentiation.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Science

  • ISSN

    0036-8075

  • e-ISSN

  • Volume of the periodical

    377

  • Issue of the periodical within the volume

    6606

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    6

  • Pages from-to

    629-634

  • UT code for WoS article

    000837874700039

  • EID of the result in the Scopus database

    2-s2.0-85135422039