Meiotic exit in Arabidopsis is driven by P-body-mediated inhibition of translation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F22%3A00127511" target="_blank" >RIV/00216224:14740/22:00127511 - isvavai.cz</a>
Result on the web
<a href="https://www.science.org/doi/10.1126/science.abo0904" target="_blank" >https://www.science.org/doi/10.1126/science.abo0904</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/science.abo0904" target="_blank" >10.1126/science.abo0904</a>
Alternative languages
Result language
angličtina
Original language name
Meiotic exit in Arabidopsis is driven by P-body-mediated inhibition of translation
Original language description
Meiosis, at the transition between diploid and haploid life cycle phases, is accompanied by reprograming of cell division machinery and followed by a transition back to mitosis. We show that, in Arabidopsis, this transition is driven by inhibition of translation, achieved by a mechanism that involves processing bodies (P-bodies). During the second meiotic division, the meiosis-specific protein THREE-DIVISION MUTANT 1 (TDM1) is incorporated into P-bodies through interaction with SUPPRESSOR WITH MORPHOGENETIC EFFECTS ON GENITALIA 7 (SMG7). TDM1 attracts eIF4F, the main translation initiation complex, temporarily sequestering it in P-bodies and inhibiting translation. The failure of tdm1 mutants to terminate meiosis can be overcome by chemical inhibition of translation. We propose that TDM1-containing P-bodies down-regulate expression of meiotic transcripts to facilitate transition of cell fates to postmeiotic gametophyte differentiation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Science
ISSN
0036-8075
e-ISSN
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Volume of the periodical
377
Issue of the periodical within the volume
6606
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
629-634
UT code for WoS article
000837874700039
EID of the result in the Scopus database
2-s2.0-85135422039