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A CENH3 mutation promotes meiotic exit and restores fertility in SMG7-deficient Arabidopsis

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F21%3A00124389" target="_blank" >RIV/00216224:14740/21:00124389 - isvavai.cz</a>

  • Result on the web

    <a href="https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009779" target="_blank" >https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009779</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1371/journal.pgen.1009779" target="_blank" >10.1371/journal.pgen.1009779</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    A CENH3 mutation promotes meiotic exit and restores fertility in SMG7-deficient Arabidopsis

  • Original language description

    Meiosis in angiosperm plants is followed by mitotic divisions to form multicellular haploid gametophytes. Termination of meiosis and transition to gametophytic development is, in Arabidopsis, governed by a dedicated mechanism that involves SMG7 and TDM1 proteins. Mutants carrying the smg7-6 allele are semi-fertile due to reduced pollen production. We found that instead of forming tetrads, smg7-6 pollen mother cells undergo multiple rounds of chromosome condensation and spindle assembly at the end of meiosis, resembling aberrant attempts to undergo additional meiotic divisions. A suppressor screen uncovered a mutation in centromeric histone H3 (CENH3) that increased fertility and promoted meiotic exit in smg7-6 plants. The mutation led to inefficient splicing of the CENH3 mRNA and a substantial decrease of CENH3, resulting in smaller centromeres. The reduced level of CENH3 delayed formation of the mitotic spindle but did not have an apparent effect on plant growth and development. We suggest that impaired spindle re-assembly at the end of meiosis limits aberrant divisions in smg7-6 plants and promotes formation of tetrads and viable pollen. Furthermore, the mutant with reduced level of CENH3 was very inefficient haploid inducer indicating that differences in centromere size is not the key determinant of centromere-mediated genome elimination.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10603 - Genetics and heredity (medical genetics to be 3)

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    PLoS Genetics

  • ISSN

    1553-7404

  • e-ISSN

    1553-7390

  • Volume of the periodical

    17

  • Issue of the periodical within the volume

    9

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    26

  • Pages from-to

    „e1009779“

  • UT code for WoS article

    000757101300002

  • EID of the result in the Scopus database

    2-s2.0-85116890494