The utility of -synuclein as biofluid marker in neurodegenerative diseases: a systematic review of the literature
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F16%3A00089458" target="_blank" >RIV/00216224:14740/16:00089458 - isvavai.cz</a>
Result on the web
<a href="http://www.futuremedicine.com/doi/10.2217/BMM.14.105" target="_blank" >http://www.futuremedicine.com/doi/10.2217/BMM.14.105</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2217/BMM.14.105" target="_blank" >10.2217/BMM.14.105</a>
Alternative languages
Result language
angličtina
Original language name
The utility of -synuclein as biofluid marker in neurodegenerative diseases: a systematic review of the literature
Original language description
The discovery of -synuclein (-syn) as a major component of Lewy bodies, neuropathological hallmark of Parkinson's disease (PD), dementia with Lewy bodies and of glial inclusions in multiple system atrophy initiated the investigation of -syn as a biomarker in cerebrospinal fluid (CSF). Due to the involvement of the periphery in PD the quantification of -syn in peripheral fluids such as serum, plasma and saliva has been investigated as well. We review how the development of multiple assays for the quantification of -syn has yielded novel insights into the variety of -syn species present in the different fluids; the optimal preanalytical conditions required for robust quantification and the potential clinical value of -syn as biomarker. We also suggest future approaches to use of CSF -syn in neurodegenerative diseases.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BIOMARKERS IN MEDICINE
ISSN
1752-0363
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
16
Pages from-to
19-34
UT code for WoS article
000367011600004
EID of the result in the Scopus database
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