Biological confounders for the values of cerebrospinal fluid proteins in Parkinson's disease and related disorders
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F16%3A00092576" target="_blank" >RIV/00216224:14740/16:00092576 - isvavai.cz</a>
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1111/jnc.13390/epdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/jnc.13390/epdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/jnc.13390" target="_blank" >10.1111/jnc.13390</a>
Alternative languages
Result language
angličtina
Original language name
Biological confounders for the values of cerebrospinal fluid proteins in Parkinson's disease and related disorders
Original language description
Cerebrospinal fluid (CSF) has been extensively studied to explore biochemical alterations in subjects with neurodegenerative disorders. In Alzheimer's disease, levels of increased CSF tau protein and decreased levels of -amyloid 1-42 (A42) have been shown to correlate with brain plaque formation and tangle pathology. Intracellular Lewy inclusions containing aggregated -synuclein (-syn) represent a pathological hallmark of Parkinson's disease (PD). In most - but not all - studies published to date total CSF -syn concentrations have been found to be decreased in disorders related to -syn pathology, that is, PD, dementia with Lewy bodies and multiple system atrophy. However, these reports show extensive signal overlap among tested individuals, thereby diminishing its potential for routine use in clinical practice. To investigate potential biological (i.e.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Neurochemistry
ISSN
0022-3042
e-ISSN
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Volume of the periodical
139
Issue of the periodical within the volume
October
Country of publishing house
US - UNITED STATES
Number of pages
28
Pages from-to
290-317
UT code for WoS article
000385770500019
EID of the result in the Scopus database
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