Dynamics of Individual T Cell Repertoires: From Cord Blood to Centenarians

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F16%3A00090973" target="_blank" >RIV/00216224:14740/16:00090973 - isvavai.cz</a>

Result on the web

<a href="http://www.jimmunol.org/content/196/12/5005" target="_blank" >http://www.jimmunol.org/content/196/12/5005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4049/jimmunol.1600005" target="_blank" >10.4049/jimmunol.1600005</a>

Result language

angličtina

Original language name

Dynamics of Individual T Cell Repertoires: From Cord Blood to Centenarians

Original language description

The diversity, architecture, and dynamics of the TCR repertoire largely determine our ability to effectively withstand infections and malignancies with minimal mistargeting of immune responses. In this study, we have employed deep TCRb repertoire sequencing with normalization based on unique molecular identifiers to explore the long-term dynamics of T cell immunity. We demonstrate remarkable stability of repertoire, where approximately half of all T cells in peripheral blood are represented by clones that persist and generally preserve their frequencies for 3 y. We further characterize the extremes of lifelong TCR repertoire evolution, analyzing samples ranging from umbilical cord blood to centenarian peripheral blood. We show that the fetal TCR repertoire, albeit structurally maintained within regulated borders due to the lower numbers of randomly added nucleotides, is not limited with respect to observed functional diversity.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FN - Epidemiology, infection diseases and clinical immunology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of immunology

ISSN

0022-1767

e-ISSN

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Volume of the periodical

196

Issue of the periodical within the volume

12

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

5005-5013

UT code for WoS article

000377937500018

EID of the result in the Scopus database

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