Loss of Nat4 and its associated histone H4 N-terminal acetylation mediates calorie restriction-induced longevity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F16%3A00091870" target="_blank" >RIV/00216224:14740/16:00091870 - isvavai.cz</a>

Result on the web

<a href="http://embor.embopress.org/content/early/2016/10/31/embr.201642540.long" target="_blank" >http://embor.embopress.org/content/early/2016/10/31/embr.201642540.long</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.15252/embr.201642540" target="_blank" >10.15252/embr.201642540</a>

Result language

angličtina

Original language name

Loss of Nat4 and its associated histone H4 N-terminal acetylation mediates calorie restriction-induced longevity

Original language description

Changes in histone modifications are an attractive model through which environmental signals, such as diet, could be integrated in the cell for regulating its lifespan. However, evidence linking dietary interventions with specific alterations in histone modifications that subsequently affect lifespan remains elusive. We show here that deletion of histone N-alpha-terminal acetyltransferase Nat4 and loss of its associated H4 N-terminal acetylation (N-acH4) extend yeast replicative lifespan. Notably, nat4-induced longevity is epistatic to the effects of calorie restriction (CR). Consistent with this, (i) Nat4 expression is downregulated and the levels of N-acH4 within chromatin are reduced upon CR, (ii) constitutive expression of Nat4 and maintenance of N-acH4 levels reduces the extension of lifespan mediated by CR, and (iii) transcriptome analysis indicates that nat4 largely mimics the effects of CR, especially in the induction of stress-response genes.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

EMBO reports

ISSN

1469-221X

e-ISSN

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Volume of the periodical

17

Issue of the periodical within the volume

12

Country of publishing house

US - UNITED STATES

Number of pages

15

Pages from-to

1829-1843

UT code for WoS article

000389329400019

EID of the result in the Scopus database

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