Reliability of immune receptor rearrangements as genetic markers for minimal residual disease monitoring
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F16%3A00092572" target="_blank" >RIV/00216224:14740/16:00092572 - isvavai.cz</a>
Result on the web
<a href="http://www.nature.com/bmt/journal/v51/n10/pdf/bmt2016148a.pdf" target="_blank" >http://www.nature.com/bmt/journal/v51/n10/pdf/bmt2016148a.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/bmt.2016.148" target="_blank" >10.1038/bmt.2016.148</a>
Alternative languages
Result language
angličtina
Original language name
Reliability of immune receptor rearrangements as genetic markers for minimal residual disease monitoring
Original language description
Detection of minimal residual disease (MRD) is a powerful prognostic tool in many hematological malignancies including ALL. Several groups of markers are widely used to monitor the concentration of a malignant clone including the detection of 'clonal B-cell (BCR) or T-cell (TCR) gene receptor rearrangements in ALL. Identification of a clonal rearrangement specific for the malignant clone, which usually constitutes from 20 to 90% in the initial bone marrow sample is a relatively straightforward task. Tracking this rearrangement after therapy is more tricky as the concentration of malignant cells in the sample can be very low. Recent progress in MRD detection based on quantitative real-time PCR (qPCR) and highthroughput sequen- cing (HTS) allows to detect malignant clones present at a concentration of one per 10 and even per 10 cells.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bone Marrow Transplantation
ISSN
0268-3369
e-ISSN
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Volume of the periodical
51
Issue of the periodical within the volume
10
Country of publishing house
GB - UNITED KINGDOM
Number of pages
3
Pages from-to
1408-1410
UT code for WoS article
000385733800025
EID of the result in the Scopus database
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