IGH Rearrangement Evolution in Adult <i>KMT2A</i>-rearranged B-cell Precursor ALL: Implications for Cell-of-origin and MRD Monitoring
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F23%3A00133316" target="_blank" >RIV/00216224:14740/23:00133316 - isvavai.cz</a>
Result on the web
<a href="https://journals.lww.com/hemasphere/fulltext/2023/01000/igh_rearrangement_evolution_in_adult.6.aspx" target="_blank" >https://journals.lww.com/hemasphere/fulltext/2023/01000/igh_rearrangement_evolution_in_adult.6.aspx</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/HS9.0000000000000820" target="_blank" >10.1097/HS9.0000000000000820</a>
Alternative languages
Result language
angličtina
Original language name
IGH Rearrangement Evolution in Adult <i>KMT2A</i>-rearranged B-cell Precursor ALL: Implications for Cell-of-origin and MRD Monitoring
Original language description
B lymphoid neoplasms originate from a single malignantly transformed immune cell, whose immunoglobulin heavy chain (IGH) rearrangement profile is carried by the entire expanded malignant population and mirrors its differentiation status. However, in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) and depending on the developmental stage of malignant transformation, multiple new but related IGH rearrangements may result from RAG-mediated recombination that may still be active in the malignant clone. Moreover, such phenomena complicate the identification of molecular minimal residual disease (MRD) markers and have implications for MRD monitoring. Therefore, deep analysis of IGH gene rearrangement patterns and clonal evolution mechanisms may allow new insights into the stage of B-cell differentiation arrest of the leukemia-driving subpopulation that ultimately determines the outcome, and provide more accurate MRD results.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
HemaSphere
ISSN
2572-9241
e-ISSN
2572-9241
Volume of the periodical
7
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
1-4
UT code for WoS article
000901500500004
EID of the result in the Scopus database
2-s2.0-85144941419