Large-scale cortico-subcortical functional networks in focal epilepsies: The role of the basal ganglia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F17%3A00094611" target="_blank" >RIV/00216224:14740/17:00094611 - isvavai.cz</a>

Alternative codes found

RIV/00159816:_____/17:00067201

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S2213158216302510?via%3Dihub" target="_blank" >http://www.sciencedirect.com/science/article/pii/S2213158216302510?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.nicl.2016.12.014" target="_blank" >10.1016/j.nicl.2016.12.014</a>

Result language

angličtina

Original language name

Large-scale cortico-subcortical functional networks in focal epilepsies: The role of the basal ganglia

Original language description

Objectives: The aimwas to describe the contribution of basal ganglia (BG) thalamo-cortical circuitry to thewholebrain functional connectivity in focal epilepsies. Methods: Interictal resting-state fMRI recordings were acquired in 46 persons with focal epilepsies. Of these 46, 22 had temporal lobe epilepsy: 9 left temporal (LTLE), 13 right temporal (RTLE); 15 had frontal lobe epilepsy (FLE); and 9 had parietal/ occipital lobe epilepsy (POLE). There were 20 healthy controls. The completeweighted networkwas analyzed based on correlation matrices of 90 and 194 regions. The network topologywas quantified on a global and regional level by measures based on graph theory, and connection-level changes were analyzed by the partial least square method. Results: In all patient groups except RTLE, the shift of the functional network topology away from random was observed (normalized clustering coefficient and characteristic path length were higher in patient groups than in controls). Links contributing to this change were found in the cortico-subcortical connections. Weak connections (low correlations) consistently contributed to thismodification of the network. The importance of regions changed: decreases in the subcortical areas and both decreases and increases in the cortical areas were observed in node strength, clustering coefficient and eigenvector centrality in patient groups when compared to controls. Node strength decreases of the basal ganglia, i.e. the putamen, caudate, and pallidum, were displayed in LTLE, FLE, and POLE. The connectivity within the basal ganglia-thalamus circuitry was not disturbed; the disturbance concerned the connectivity between the circuitry and the cortex. Significance: Focal epilepsies affect large-scale brain networks beyond the epileptogenic zones. Cortico-subcortical functional connectivity disturbance was displayed in LTLE, FLE, and POLE. Significant changes in the restingstate functional connectivity between cortical and subcortical structures suggest an important role of the BG and thalamus in focal epilepsies.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

NeuroImage-Clinical

ISSN

2213-1582

e-ISSN

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Volume of the periodical

2017

Issue of the periodical within the volume

14

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

28-36

UT code for WoS article

000405984300003

EID of the result in the Scopus database

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