Cognitive task-related functional connectivity alterations in temporal lobe epilepsy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F20%3A00535328" target="_blank" >RIV/68081731:_____/20:00535328 - isvavai.cz</a>

Alternative codes found

RIV/00159816:_____/20:00073360 RIV/00216224:14740/20:00118636

Result on the web

<a href="https://www.sciencedirect.com/science/article/abs/pii/S1525505020305886" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S1525505020305886</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.yebeh.2020.107409" target="_blank" >10.1016/j.yebeh.2020.107409</a>

Result language

angličtina

Original language name

Cognitive task-related functional connectivity alterations in temporal lobe epilepsy

Original language description

We investigated cognitive task-related functional connectivity (FC) in patients with temporal lobe epilepsy (TLE). Using a visual three-stimulus paradigm (VTSP), we studied cognitive large-scale networks and the impact of TLE on connectivity outside the temporal lobe. Methods: High-density electroencephalography (EEG) was recorded during the paradigm from nineteen patients with epilepsy with hippocampal sclerosis (HS) and ten healthy controls (HCs). Scalp data were reconstructed into the source space, and FC was computed. Correlating with the neuropsychological data, possible compensatory mechanisms were investigated. Results: Significant changes were found in the FC of regions outside the epileptogenic network, particularly in the attentional network. These changes were more widespread in left TLE (LTLE). There were no significant differences in task performance (accuracy, time response) in comparison with HCs, implying that there must be some mechanism reducing the impact of connectivity changes on brain functions. When correlated with neuropsychological data, we found stronger compensatory mechanisms in right TLE (RTLE). Significance: Our findings confirm the hypothesis that LTLE is the more pervasive form of the disease. Even though the network alterations in TLE are severe, some mechanisms reduce the impact of epilepsy on cognitive functions, these mechanisms are more potent in RTLE. We also suggest that there are maladaptive mechanisms in LTLE.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

20601 - Medical engineering

Project

<a href="/en/project/NV17-32292A" target="_blank" >NV17-32292A: Lesion detection in non-lesional epilepsies using multimodal imaging methods</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Epilepsy and Behavior

ISSN

1525-5050

e-ISSN

—

Volume of the periodical

112

Issue of the periodical within the volume

NOV

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

107409

UT code for WoS article

000588004200075

EID of the result in the Scopus database

2-s2.0-85090362160