Immunoglobulin genes in chronic lymphocytic leukemia: key to understanding the disease and improving risk stratification

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F17%3A00095656" target="_blank" >RIV/00216224:14740/17:00095656 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.3324/haematol.2017.165605" target="_blank" >http://dx.doi.org/10.3324/haematol.2017.165605</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3324/haematol.2017.165605" target="_blank" >10.3324/haematol.2017.165605</a>

Result language

angličtina

Original language name

Immunoglobulin genes in chronic lymphocytic leukemia: key to understanding the disease and improving risk stratification

Original language description

While triggering through the B-cell receptor (BcR) facilitates B-cell development and maintenance, it also carries intertwined risks for the emergence of lymphoid malignancies, since malignant B cells can exploit BcR signaling pathways in order to initiate and fuel clonal expansion. Indeed, substantial research into chronic lymphocytic leukemia (CLL), largely based on immunogenetic data, supports the notion that the clonotypic BcR immunoglobulin (IG) engages in the recognition of and selection by putative (auto)antigen.1 This highlights the critical role of the BcR IG in the pathophysiology of CLL and implies that disease development is functionally driven and dynamic, rather than being a simple stochastic process. From a clinical perspective, the remarkable therapeutic efficacy of novel drugs such as ibrutinib and idelalisib which target effectors of the BcR signaling pathway (BTK and PI3K™, respectively), further vouch for this idea, and herald a major paradigm shift which may ultimately lead to changes in the natural history of the disease

Czech name

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Czech description

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Type

J_ost - Miscellaneous article in a specialist periodical

CEP classification

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OECD FORD branch

30200 - Clinical medicine

Project

<a href="/en/project/NV15-30015A" target="_blank" >NV15-30015A: Analysis of clonal heterogeneity in chronic lymphocytic leukemia using next generation sequencing of B cell receptor. A national study.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Haematologica/the hematology journal

ISSN

0390-6078

e-ISSN

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Volume of the periodical

102

Issue of the periodical within the volume

6

Country of publishing house

IT - ITALY

Number of pages

5

Pages from-to

968-971

UT code for WoS article

000402797300009

EID of the result in the Scopus database

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