Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F17%3A00097313" target="_blank" >RIV/00216224:14740/17:00097313 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0301008215001008?via%3Dihub" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0301008215001008?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.pneurobio.2015.09.011" target="_blank" >10.1016/j.pneurobio.2015.09.011</a>
Alternative languages
Result language
angličtina
Original language name
Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms
Original language description
Amphetamine-related drugs, such as 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine (METH), are popular recreational psychostimulants. Several preclinical studies have demonstrated that, besides having the potential for abuse, amphetamine-related drugs may also elicit neurotoxic and neuroinflammatory effects. The neurotoxic potentials of MDMA and METH to dopaminergic and serotonergic neurons have been clearly demonstrated in both rodents and nonhuman primates. This review summarizes the species-specific cellular and molecular mechanisms involved in MDMA and METH-mediated neurotoxic and neuroinflammatory effects, along with the most important behavioral changes elicited by these substances in experimental animals and humans. Emphasis is placed on the neuropsychological and neurological consequences associated with the neuronal damage. Moreover, we point out the gap in our knowledge and the need for developing appropriate therapeutic strategies to manage the neurological problems associated with amphetamine-related drug abuse. (C) 2015 Elsevier Ltd. All rights reserved.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PROGRESS IN NEUROBIOLOGY
ISSN
0301-0082
e-ISSN
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Volume of the periodical
155
Issue of the periodical within the volume
August
Country of publishing house
GB - UNITED KINGDOM
Number of pages
22
Pages from-to
149-170
UT code for WoS article
000403544300009
EID of the result in the Scopus database
2-s2.0-85020865433