Clonal selection in the human V delta 1 T cell repertoire indicates gamma delta TCR-dependent adaptive immune surveillance

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F17%3A00100337" target="_blank" >RIV/00216224:14740/17:00100337 - isvavai.cz</a>

Result on the web

<a href="https://www.nature.com/articles/ncomms14760.pdf" target="_blank" >https://www.nature.com/articles/ncomms14760.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/ncomms14760" target="_blank" >10.1038/ncomms14760</a>

Result language

angličtina

Original language name

Clonal selection in the human V delta 1 T cell repertoire indicates gamma delta TCR-dependent adaptive immune surveillance

Original language description

gamma delta Tcells are considered to be innate-like lymphocytes that respond rapidly to stress without clonal selection and differentiation. Here we use next-generation sequencing to probe how this paradigm relates to human V delta 2(neg) T cells, implicated in responses to viral infection and cancer. The prevalent V delta 1 T cell receptor (TCR) repertoire is private and initially unfocused in cord blood, typically becoming strongly focused on a few high-frequency clonotypes by adulthood. Clonal expansions have differentiated from a naive to effector phenotype associated with CD27 downregulation, retaining proliferative capacity and TCR sensitivity, displaying increased cytotoxic markers and altered homing capabilities, and remaining relatively stable over time. Contrastingly, V delta 2(+) T cells express semi-invariant TCRs, which are present at birth and shared between individuals. Human V delta 1(+) T cells have therefore evolved a distinct biology from the V delta 2(+) subset, involving a central, personalized role for the gamma delta TCR in directing a highly adaptive yet unconventional form of immune surveillance.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30100 - Basic medicine

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature Communications

ISSN

2041-1723

e-ISSN

—

Volume of the periodical

8

Issue of the periodical within the volume

MAR

Country of publishing house

GB - UNITED KINGDOM

Number of pages

15

Pages from-to

14760

UT code for WoS article

000395055100001

EID of the result in the Scopus database

2-s2.0-85014429718